Concept Arrow : Medicinal Chemistry & Pharmacology

        IPRATROPIUM BROMIDE [(1R,5S)-8-methyl-8-propan-2-yl-8-azabicyclo[3.2.1] octane 3-yl)3-hydroxy-2-phenylpropanoate] MF: ‎C 20 H 30 NO 3 +   MW: 412.37 g/mol Properties: It is a quaternary ammonium compound formed by reaction of atropine with isopropyl alcohol. It is hydrolyzed by acid and alkali. It is soluble in water and alcohol but insoluble in ether and chloroform. MOA: It produces broncholytic activity through inhibition of influence of ACh in bronchial muscle. It inhibits constriction of bronchioles and secretion from muscle. It produces non selective antagonistic activity in Muscarinic receptor and promotes degradation of cGMP which results in decreased level of intracellular Ca ++ and thus contraction rate of smooth muscle in lungs.     Use:   It is used in COPD (Chronic obstructive ...

 .................................... CONCEPT OF UNNATURAL AMINO ACID.................... I n several fields of chemistry, amino acids have long been crucial. Naturally, only 20 amino acids are used, but even a little alteration to one of these amino acids has resulted in an amazing diversity in terms of chemical structure and function. The likelihood of novel drugs, hormones, and enzymes originating from non-proteogenic unnatural amino acids is fast rising along with their abundance. To put it simply, unnatural amino acids are non-proteinogenic amino acids, meaning they don't belong to the 20 amino acids that are attached to tRNAs in living cells and used to polymerize proteins. While some synthetic amino acids are produced artificially, most are produced chemically. Citrulline is a good example of a non-proteinogenic amino acid that the body can produce by oxidising arginine, whereas p-benzoyl-phenylalanine is a good example of an amino acid that doesn't exist at all in n...

 What is Medicinal Chemistry........................................   M edicinal chemistry is a branch of science that deals with the discovery, design and development of new molecules for treating diseases. It is associated with interactions of biologically active compounds at the molecular level. It is an interdisciplinary science that is connected synthetic organic chemistry and  also with various biological are as such as biochemistry , molecular biology , Pharmacognosy  and Pharmacology , Toxicology .   Medicinal chemistry mainly focuses on organic compounds, which are often divided   as small organic molecules and biologics. The organic molecules can be natural or synthetic origin. The natural sources include several alkaloids, glycosides, hormones, vitamins and antibiotics. The modifications in the structure of natural drugs results in synthetic drugs like analgesics, antispasmodics, local anaesthetics and sympathomimetics. Some of the drugs ...