IPRATROPIUM BROMIDE (Properties and Synthesis)

 

   

IPRATROPIUM BROMIDE


[(1R,5S)-8-methyl-8-propan-2-yl-8-azabicyclo[3.2.1] octane 3-yl)3-hydroxy-2-phenylpropanoate]

MF: ‎C20H30NO3+  MW: 412.37 g/mol

Properties: It is a quaternary ammonium compound formed by reaction of atropine with isopropyl alcohol. It is hydrolyzed by acid and alkali. It is soluble in water and alcohol but insoluble in ether and chloroform.


MOA: It produces broncholytic activity through inhibition of influence of ACh in bronchial muscle.

It inhibits constriction of bronchioles and secretion from muscle. It produces non selective antagonistic activity in Muscarinic receptor and promotes degradation of cGMP which results in decreased level of intracellular Ca++ and thus contraction rate of smooth muscle in lungs.

 

 

Use:  It is used in COPD (Chronic obstructive pulmonary disorder) and asthma. Thus it is used in inhaler and nebulizer.


SE: Dry mouth, cough, head ach, nausea, dizziness


Dose: 2 puff is inhaled 3-4 times (17mcg= 1 puff) in COPD and asthma, 0.03-0.06% nasal spray, 500 mcg nebulizer for adult and 250-500mcg for children is used.





 

 

 


 

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